Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brain-Derived Neurotrophic Factor Val66Met Polymorphism Affects the Relationship Between an Anxiety-Related Personality Trait and Resting Regional Cerebral Blood Flow.

Cerebral cortex (New York, N.Y. : 1991) - 1 Mar 2017

Wei Shau-Ming, Eisenberg Daniel P, Nabel Katherine G, Kohn Philip D, Kippenhan J Shane, Dickinson Dwight, Kolachana Bhaskar, Berman Karen F

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) is an important modulator of constitutive stress responses mediated by limbic frontotemporal circuits, and its gene contains a functional polymorphism (Val66Met) that may influence trait stress sensitivity. Reports of an association of this polymorphism with anxiety-related personality traits have been controversial and without clear neurophysiological support. We,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Brain-Derived Neurotrophic Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Mapping

Share to Cerebrovascular Circulation

Share to Personality

Share to Personality Tests

Share to Positron-Emission Tomography

Source

Open in PubMed Open full text

Identifiers

PMID: 27005989
DOI: 10.1093/cercor/bhw072
PMCID: PMC6059093

Genes

BDNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain-Derived Neurotrophic Factor Val66Met Polymorphism Affects the Relationship Between an Anxiety-Related Personality Trait and Resting Regional Cerebral Blood Flow.PMID 27005989Read ↗

Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits.Semantic proximity Read ↗

BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects.Semantic proximity Read ↗

Meta-analysis of the brain-derived neurotrophic factor gene (BDNF) Val66Met polymorphism in anxiety disorders and anxiety-related personality traits.Semantic proximity Read ↗

BDNF Val66Met polymorphism is associated with higher anticipatory cortisol stress response, anxiety, and alcohol consumption in healthy adults.Semantic proximity Read ↗

Association of a functional BDNF polymorphism and anxiety-related personality traits.Semantic proximity Read ↗

The brain-derived neurotrophic factor Val66met polymorphism is associated with better attention and working memory performance and resilience to mild chronic stress.Semantic proximity Read ↗

BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents.Semantic proximity Read ↗

Early life stress combined with serotonin 3A receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression.Semantic proximity Read ↗

The BDNF Val66Met polymorphism and anxiety: support for animal knock-in studies from a genetic association study in humans.Semantic proximity Read ↗

Brain-derived neurotrophic factor Val⁶⁶Met polymorphism affects resting regional cerebral blood flow and functional connectivity differentially in women versus men.Semantic proximity Read ↗

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism affects sympathetic tone in a gender-specific way.Semantic proximity Read ↗

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.