Article
BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2005
Jiang Xueying, Xu Ke, Hoberman Joelle, Tian Feng, Marko Aimee J, Waheed Juwaria F, Harris Claudia R, Marini Ann M, Enoch Mary-Anne, Lipsky Robert H
Abstract excerpt
The brain-derived neurotrophic factor (BDNF) gene is critical for neuronal function and survival, and is likely to be important in psychiatric disorders. In this study, we used single-nucleotide polymorphism (SNP) discovery, functional analyses, and genetic association studies to better understand the potential role of BDNF sequence variation in behavior. Screening 480 unrelated individuals for SNPs and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.