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Article

Brain-derived neurotrophic factor Val⁶⁶Met polymorphism affects resting regional cerebral blood flow and functional connectivity differentially in women versus men.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 May 2012

Wei Shau-Ming, Eisenberg Daniel P, Kohn Philip D, Kippenhan Jonathan S, Kolachana Bhaskar S, Weinberger Daniel R, Berman Karen F

Abstract excerpt

The human Val⁶⁶Met single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene impacts BDNF signaling at the cellular level. At the neural-systems level, it is associated with differences in prefrontal cortex (PFC) and hippocampal function during performance of cognitive and affective tasks. Because the impact of this variant on basal prefrontal and hippocampal activity is not known but...

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Source

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Identifiers

PMID: 22593075
DOI: 10.1523/JNEUROSCI.5375-11.2012
PMCID: PMC3362630

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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