Article
Plasma Levels of Risk-Variant APOL1 Do Not Associate with Renal Disease in a Population-Based Cohort.
Journal of the American Society of Nephrology : JASN - 1 Oct 2016
Kozlitina Julia, Zhou Haihong, Brown Patricia N, Rohm Rory J, Pan Yi, Ayanoglu Gulesi, Du Xiaoyan, Rimmer Eric, Reilly Dermot F, Roddy Thomas P, Cully Doris F, Vogt Thomas F, Blom Daniel, Hoek Maarten
Abstract excerpt
Two common missense variants in APOL1 (G1 and G2) have been definitively linked to CKD in black Americans. However, not all individuals with the renal-risk genotype develop CKD, and little is known about how APOL1 variants drive disease. Given the association of APOL1 with HDL particles, which are cleared by the kidney, differences in the level or quality of mutant APOL1‑HDL particles could be causal for disease...
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