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Article

Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.

Journal of cell science - 1 Feb 2017

Nozaki Shohei, Katoh Yohei, Terada Masaya, Michisaka Saki, Funabashi Teruki, Takahashi Senye, Kontani Kenji, Nakayama Kazuhisa

Abstract excerpt

ARL13B (a small GTPase) and INPP5E (a phosphoinositide 5-phosphatase) are ciliary proteins encoded by causative genes of Joubert syndrome. We here showed, by taking advantage of a visible immunoprecipitation assay, that ARL13B interacts with the IFT46 -: IFT56 (IFT56 is also known as TTC26) dimer of the intraflagellar transport (IFT)-B complex, which mediates anterograde ciliary protein trafficking. However, the...

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Source

Identifiers

PMID: 27927754
DOI: 10.1242/jcs.197004

Genes

IFT56
IFT46

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.PMID 27927754Read ↗

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Unraveling the Intricate Cargo-BBSome Coupling Mechanism at the Ciliary TipSemantic proximity Read ↗

Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry.Semantic proximity Read ↗

ARL3 mediates BBSome ciliary turnover by promoting its outward movement across the transition zoneSemantic proximity Read ↗

Arl3 regulates ODA16-mediated intraflagellar transport in motile cilia biogenesisSemantic proximity Read ↗

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Architecture of the IFT ciliary trafficking machinery and interplay between its componentsSemantic proximity Read ↗

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