Article
G-protein-coupled receptor signaling and neural tube closure defects.
Birth defects research - 30 Jan 2017
Shimada Issei S, Mukhopadhyay Saikat
Abstract excerpt
Disruption of the normal mechanisms that mediate neural tube closure can result in neural tube defects (NTDs) with devastating consequences in affected patients. With the advent of next-generation sequencing, we are increasingly detecting mutations in multiple genes in NTD cases. However, our ability to determine which of these genes contribute to the malformation is limited by our understanding of the pathways...
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