Article

Depletion of BBSome Subunits Alters Receptor Endocytosis and Promotes EMT via TGF-β Signaling

2024-10-24

Abstract excerpt

<h4>Summary</h4> Ciliopathies are genetic disorders caused by defects in the structure or function of the cilia and their related structures. Bardet-Biedl syndrome (BBS) is a complex ciliopathy with varied symptoms, probably due to altered membrane receptor signalling pathways. This study explores the role of BBS1 and BBS4 gene deficiencies in receptor trafficking and epithelial-mesenchymal transition (EMT) in...

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Literature Corpus work: 19db8dc8-54bd-55de-9608-14ce284b367f
DOI: 10.1101/2024.10.23.619933

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