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Article

GPR88 Reveals a Discrete Function of Primary Cilia as Selective Insulators of GPCR Cross-Talk

2 Aug 2013

Abstract excerpt

A number of G protein-coupled receptors (GPCRs) localize to primary cilia but the functional significance of cilia to GPCR signaling remains incompletely understood. We investigated this question by focusing on the D1 dopamine receptor (D1R) and beta-2 adrenergic receptor (B2AR), closely related catecholamine receptors that signal by stimulating production of the diffusible second messenger cyclic AMP (cAMP) but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23936473
DOI: 10.1371/journal.pone.0070857

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