Article
Rhodopsin Trafficking and Mistrafficking: Signals, Molecular Components, and Mechanisms.
Progress in molecular biology and translational science - 1 Jan 2015
Nemet Ina, Ropelewski Philip, Imanishi Yoshikazu
Abstract excerpt
Rhodopsin is a seven-transmembrane G protein-coupled receptor (GPCR) and is the main component of the photoreceptor outer segment (OS), a ciliary compartment essential for vision. Because the OSs are incapable of protein synthesis, rhodopsin must first be synthesized in the inner segments (ISs) and subsequently trafficked across the connecting cilia to the OSs where it participates in the phototransduction...
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