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Article

Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development

14 Apr 2017

Abstract excerpt

What pathways specify retinal ganglion cell (RGC) fate in the developing retina? Here we report on mechanisms by which a molecular pathway involving Sox4/Sox11 is required for RGC differentiation and for optic nerve formation in micein vivo, and is sufficient to differentiate human induced pluripotent stem cells into electrophysiologically active RGCs. These data place Sox4 downstream of RE1 silencing...

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PMID: 28411269
DOI: 10.1523/jneurosci.3430-13.2017

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