Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells.

Cancer discovery - 1 May 2016

Godek Kristina M, Venere Monica, Wu Quilian, Mills Kevin D, Hickey William F, Rich Jeremy N, Compton Duane A

Abstract excerpt

UNLABELLED: Tumors are dynamic organs that evolve during disease progression with genetic, epigenetic, and environmental differences among tumor cells serving as the foundation for selection and evolution in tumors. Tumor-initiating cells (TIC) that are responsible for tumorigenesis are a source of functional cellular heterogeneity, whereas chromosomal instability (CIN) is a source of karyotypic genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal Instability
Share to Chromosome Segregation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Fragmentation

Share to Genetic Heterogeneity

Share to Glioblastoma

Share to Heterografts

Share to In Situ Hybridization, Fluorescence

Share to Neoplastic Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 27001151
DOI: 10.1158/2159-8290.CD-15-1154
PMCID: PMC4854766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells.PMID 27001151Read ↗

Chromosomal instability: a key driver in glioma pathogenesis and progressionSemantic proximity Read ↗

Glioblastoma-initiating cell heterogeneity generated by the cell-of-origin, genetic/epigenetic mutation and microenvironment.Semantic proximity Read ↗

Heterogeneity of cancer-initiating cells within glioblastomaSemantic proximity Read ↗

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.Semantic proximity Read ↗

Intra-tumor heterogeneity, turnover rate and karyotype space shape susceptibility to missegregation-induced extinctionSemantic proximity Read ↗

How to be good at being bad: centrosome amplification and mitotic propensity drive intratumoral heterogeneity.Semantic proximity Read ↗

Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cellsSemantic proximity Read ↗

Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistanceSemantic proximity Read ↗

Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneitySemantic proximity Read ↗

Primary glioblastoma cells for precision medicine: a quantitative portrait of genomic (in)stability during the first 30 passagesSemantic proximity Read ↗

Genomic Instability in Cancer: Teetering on the Limit of ToleranceSemantic proximity Read ↗

Genomic instability en route to and from cancer stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.