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Genomic Instability in Cancer: Teetering on the Limit of Tolerance

22 Apr 2017

Abstract excerpt

Abstract Cancer genomic instability contributes to the phenomenon of intratumoral genetic heterogeneity, provides the genetic diversity required for natural selection, and enables the extensive phenotypic diversity that is frequently observed among patients. Genomic instability has previously been associated with poor prognosis. However, we have evidence that for solid tumors of epithelial origin, extreme levels...

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PMID: 28432052
DOI: 10.1158/0008-5472.can-16-1553

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