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Article

How to be good at being bad: centrosome amplification and mitotic propensity drive intratumoral heterogeneity.

Cancer metastasis reviews - 1 Dec 2015

Rida Padmashree C G, Cantuaria Guilherme, Reid Michelle D, Kucuk Omer, Aneja Ritu

Abstract excerpt

Cancer is truly an iconic disease--a tour de force whose multiple formidable strengths can be attributed to the bewildering heterogeneity that a tumor can manifest both spatially and temporally. A Darwinian evolutionary process is believed to undergird, at least in part, the generation of this heterogeneity that contributes to poor clinical outcomes. Risk assessment in clinical oncology is currently based on a...

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Source

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Identifiers

PMID: 26358854
DOI: 10.1007/s10555-015-9590-0
PMCID: PMC4778553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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