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Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity

7 Aug 2018

Abstract excerpt

Centrosomes serve as the major microtubule organizing centers in cells and thereby contribute to cell shape, polarity, and motility. Also, centrosomes ensure equal chromosome segregation during mitosis. Centrosome aberrations arise when the centrosome cycle is deregulated, or as a result of cytokinesis failure. A long-standing postulate is that centrosome aberrations are involved in the initiation and progression...

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PMID: 30381801
DOI: 10.20517/2394-4722.2018.24

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