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Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells

31 May 2019

Abstract excerpt

BACKGROUND: Intra-tumor heterogeneity stems from genetic, epigenetic, functional, and environmental differences among tumor cells. A major source of genetic heterogeneity comes from DNA sequence differences and/or whole chromosome and focal copy number variations (CNVs). Whole chromosome CNVs are caused by chromosomal instability (CIN) that is defined by a persistently high rate of chromosome mis-segregation....

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PMID: 31151460
DOI: 10.1186/s12920-019-0532-5

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