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Glioblastoma-initiating cell heterogeneity generated by the cell-of-origin, genetic/epigenetic mutation and microenvironment.

Seminars in cancer biology - 1 Jul 2022

Kondo Toru

Abstract excerpt

Glioblastoma (GBM) and other malignant tumours consist of heterogeneous cancer cells, including GBM-initiating cells (GICs). This heterogeneity is likely to arise from the following: different sets of genetic mutations and epigenetic modifications, which GICs gain in the transformation process; differences in cells of origin, such as stem cells, precursor cells or differentiated cells; and the cancer...

Topics

Brain Neoplasms
Cell Line, Tumor
Drug Resistance, Neoplasm
Endothelial Cells
Epigenesis, Genetic
Glioblastoma
Humans
Mutation
Neoplastic Stem Cells
Tumor Microenvironment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33453403
DOI: 10.1016/j.semcancer.2020.12.003

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