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Article

The role of IL18-607C>A and IL18-137G>C promoter polymorphisms in antidepressant treatment phenotypes: A preliminary report.

Neuroscience letters - 27 May 2016

Santos Marlene, Carvalho Serafim, Lima Luís, Mota-Pereira Jorge, Pimentel Paulo, Maia Dulce, Correia Diana, Gomes Sofia, Cruz Agostinho, Medeiros Rui

Abstract excerpt

Recent studies suggest that immune activation and cytokines, such as IL-18, are involved in depression. IL-18 is expressed in brain and is increased in patients with moderate to severe depression. In this study we aim to evaluate the role of IL18-607C>A and IL18-137G>C promoter polymorphisms in antidepressant treatment phenotypes, specifically relapse and treatment resistant depression (TRD). We genotyped the...

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Identifiers

PMID: 27001087
DOI: 10.1016/j.neulet.2016.03.026

Genes

TRD

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