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Article

Interleukin-1β (C-511T) Genetic Variant and Major Depressive Disorder: A Systematic Review.

International journal of molecular sciences - 3 Jul 2026

Rodrigues Gontijo Bruna, Ferreira Fratelli Caroline, Sousa Silva Bonasser Larissa, de Souza Silva Calliandra Maria, Rodrigues da Silva Izabel Cristina

Abstract excerpt

Major Depressive Disorder (MDD) has a multifactorial etiology and pathogenesis that significantly impacts an individual's quality of life. One of the possible correlations for its onset is the activation of inflammatory responses resulting in neurodegeneration and, consequently, the emergence of depressive symptoms. Interleukin-1β is a regulatory cytokine of the immune and nervous systems that acts on several...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42450240
DOI: 10.3390/ijms27135974
PMCID: PMC13361593

Genes

IL1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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