Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events.

Journal of affective disorders - 1 Jan 2012

Haastrup Eva, Bukh Jens Drachmann, Bock Camilla, Vinberg Maj, Thørner Lise Wegner, Hansen Thomas, Werge Thomas, Kessing Lars Vedel, Ullum Henrik

Abstract excerpt

BACKGROUND: Depression is accompanied by an inflammatory reaction and activation of cell mediated immunity (CMI) and stressors may induce the cytokine network in humans. The proinflammatory cytokine interleukin-18 (IL-18) is less investigated in depression but highly relevant since it is produced by activated macrophages and expressed in the brain. METHODS: The distribution of six polymorphisms in IL10, IL18 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Depression
Share to Interleukin-10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-18

Share to Life Change Events

Share to Promoter Regions, Genetic

Share to Stress, Psychological

Share to Tumor Necrosis Factor-alpha

Share to Young Adult

Source

Identifiers

PMID: 21962565
DOI: 10.1016/j.jad.2011.08.025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events.PMID 21962565Read ↗

The role of IL18-607C>A and IL18-137G>C promoter polymorphisms in antidepressant treatment phenotypes: A preliminary report.Semantic proximity Read ↗

Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder.Semantic proximity Read ↗

The impact of IL18 gene polymorphisms on mRNA levels and interleukin-18 release by peripheral blood mononuclear cells.Semantic proximity Read ↗

Genetic Contributions of Inflammation to DepressionSemantic proximity Read ↗

Interleukin-1β (C-511T) Genetic Variant and Major Depressive Disorder: A Systematic Review.Semantic proximity Read ↗

Plasma levels of Interleukin 18 but not amyloid-β or Tau are elevated in female depressive patients.Semantic proximity Read ↗

The role of pro-inflammatory cytokine gene polymorphisms in major depressive disorder: a systematic review.Semantic proximity Read ↗

Effects of chronic interpersonal stress exposure on depressive symptoms are moderated by genetic variation at IL6 and IL1β in youth.Semantic proximity Read ↗

Complex Neurobiological Mechanisms and Risk Factors Underlying Late-Life Depression.Semantic proximity Read ↗

Interleukin-18 genetics and inflammatory disease susceptibility.Semantic proximity Read ↗

The role of immune genes in the association between depression and inflammation: a review of recent clinical studies.Semantic proximity Read ↗

A Functional Interleukin-18 Haplotype Predicts Depression and Anxiety through Increased Threat-Related Amygdala Reactivity in Women but Not Men.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.