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Article

Interleukin-18 gene promoter polymorphisms and recurrent spontaneous abortion.

European journal of obstetrics, gynecology, and reproductive biology - 1 Jan 2000

Naeimi Sirous, Ghiam Alireza Fotouhi, Mojtahedi Zahra, Dehaghani Alamtaj Samsami, Amani Dawar, Ghaderi Abbas

Abstract excerpt

BACKGROUND: IL-18 is a multifunctional cytokine capable of inducing either Th1 or Th2 polarization depending on the immunologic milieu. IL-18 is detected at the materno-fetal interface very soon in early pregnancy. Two polymorphisms in the promoter region of the IL-18 gene at positions of -607 and -137 appear to have functional impacts. OBJECTIVE: This study attempts to evaluate the frequency of these two...

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Source

Identifiers

PMID: 16584830
DOI: 10.1016/j.ejogrb.2006.02.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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