Article
Epidermal filaggrin deficiency mediates increased systemic T-helper 17 immune response.
The British journal of dermatology - 1 Oct 2016
Bonefeld C M, Petersen T H, Bandier J, Agerbeck C, Linneberg A, Ross-Hansen K, Stender S, Szecsi P B, Johansen J D, Geisler C, Thyssen J P
Abstract excerpt
BACKGROUND: Cellular T-helper (Th)17 infiltrates dominate skin inflammation in filaggrin-deficient flaky tail (ft/ft) mice, and Th17 cells are found in both the skin and blood of patients with acute atopic dermatitis. However, the potential role of loss-of-function mutations in the filaggrin gene (FLG) for increased peripheral Th17 cells is unclear. OBJECTIVES: To study whether mutations in FLG influence the...
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