Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents

4 Apr 2017

Abstract excerpt

Abstract Mutations in the gene encoding for filaggrin (FLG) are major predisposing factors for atopic dermatitis (AD). Besides genetic predisposition, immunological dysregulations considerably contribute to its pathophysiology. For example, thymic stromal lymphopoietin (TSLP) is highly expressed in lesional atopic skin and significantly contributes to the pathogenesis of AD by activating dendritic cells that then...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allergic Rhinitis and Sensitization
Share to Asthma and respiratory diseases
Share to Dermatology and Skin Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28377574
DOI: 10.1038/s41598-017-00670-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalentsPMID 28377574Read ↗

IL-1β induces thymic stromal lymphopoietin and an atopic dermatitis-like phenotype in reconstructed healthy human epidermis.Semantic proximity Read ↗

The multifunctional role of filaggrin in allergic skin disease.Semantic proximity Read ↗

Epidermal filaggrin deficiency mediates increased systemic T-helper 17 immune response.Semantic proximity Read ↗

Filaggrin and beyondSemantic proximity Read ↗

Immune-mediated Skin Inflammation is Similar in Severe Atopic Dermatitis Patients With or Without Filaggrin Mutation.Semantic proximity Read ↗

One remarkable molecule: filaggrin.Semantic proximity Read ↗

Filaggrin in atopic dermatitis.Semantic proximity Read ↗

Cellular and Molecular Mechanisms of TSLP Function in Human Allergic Disorders - TSLP Programs the “Th2 code” in Dendritic CellsSemantic proximity Read ↗

Development of skin lesions in filaggrin-deficient mice is dependent on adaptive immunitySemantic proximity Read ↗

Atopic dermatitis: A tale of two distinct pathomechanisms that make you itch.Semantic proximity Read ↗

Atopic eczema and the filaggrin story.Semantic proximity Read ↗

Possible new therapeutic strategy to regulate atopic dermatitis through upregulating filaggrin expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.