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Article

Increased Production of IL-17A-Producing γδ T Cells in the Thymus of Filaggrin-Deficient Mice.

Frontiers in immunology - 1 Jan 2018

Jee Mia Hamilton, Johansen Jeanne Duus, Buus Terkild Brink, Petersen Trine Hilkjær, Gadsbøll Anne-Sofie Østergaard, Woetmann Anders, Ødum Niels, Thyssen Jacob Pontoppidan, White Andrea Jane, Anderson Graham, Geisler Carsten, Bonefeld Charlotte Menné

Abstract excerpt

Mutations in the filaggrin gene (Flg) are associated with increased systemic levels of Th17 cells and increased IL-17A production following antigen exposure in both humans and mice. In addition to Th17 cells, γδ T cells can produce IL-17A. The differentiation of γδ T cells to either IFNγ or IL-17A-producing (γδT17) cells is mainly determined in the thymus. Interestingly, it has been reported that filaggrin is...

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Identifiers

PMID: 29867965
DOI: 10.3389/fimmu.2018.00988
PMCID: PMC5953325

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