Article
IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2017
Floudas Achilleas, Saunders Sean P, Moran Tara, Schwartz Christian, Hams Emily, Fitzgerald Denise C, Johnston James A, Ogg Graham S, McKenzie Andrew N, Walsh Patrick T, Fallon Padraic G
Abstract excerpt
Atopic dermatitis (AD) is a common inflammatory skin disease affecting up to 20% of children and 3% of adults worldwide and is associated with dysregulation of the skin barrier. Although type 2 responses are implicated in AD, emerging evidence indicates a potential role for the IL-17A signaling axis in AD pathogenesis. In this study we show that in the filaggrin mutant mouse model of spontaneous AD, IL-17RA...
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