Article
Increased Th22 cell numbers in a general pediatric population with filaggrin haploinsufficiency: The Generation R Study.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Aug 2021
Looman Kirsten I M, van Mierlo Minke M F, van Zelm Menno C, Hu Chen, Duijts Liesbeth, de Jongste Johan C, Nijsten Tamar, Pardo Luba M, Kiefte-de Jong Jessica C, Moll Henriëtte A, Pasmans Suzanne G M A
Abstract excerpt
BACKGROUND: Mutations in the filaggrin gene (FLG) affect epidermal barrier function and increase the risk of atopic dermatitis (AD). We hypothesized that FLG mutations affect immune cell composition in a general pediatric population. Therefore, we investigated whether school-aged children with and without FLG mutations have differences in T- and B-cell subsets. METHODS: This study was embedded in a...
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