Article
Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency.
The Journal of allergy and clinical immunology - 1 Apr 2012
Kezic Sanja, O'Regan Gráinne M, Lutter René, Jakasa Ivone, Koster Ellen S, Saunders Sean, Caspers Peter, Kemperman Patrick M J H, Puppels Gerwin J, Sandilands Aileen, Chen Huijia, Campbell Linda E, Kroboth Karin, Watson Rosemarie, Fallon Padraic G, McLean W H Irwin, Irvine Alan D
Abstract excerpt
BACKGROUND: Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) components and consequent increased SC pH. Because higher pH activates SC protease activity, we hypothesized an enhanced release of proinflammatory IL-1 cytokines from corneocytes in patients with atopic dermatitis (AD) with FLG mutations (AD(FLG)) compared with that seen in patients with AD without...
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