Article
Novel PSEN1 and PSEN2 Mutations Identified in Sporadic Early-onset Alzheimer Disease and Posterior Cortical Atrophy.
Alzheimer disease and associated disorders - 1 Jan 2000
Li Xu-Ying, Cui Yue, Jing Donglai, Xie Kexin, Zhong Xiaoling, Kong Yu, Wang Yuting, Chu Min, Wang Chaodong, Wu Liyong
Abstract excerpt
BACKGROUND/PURPOSE: Sporadic early-onset Alzheimer disease (sEOAD) and its visual variant, posterior cortical atrophy (PCA), have a disease onset at less than 65 years of age with no familial aggregation. The etiology and genetic basis of these diseases remain poorly understood. Our study aimed to identify additional mutations or variants associated with sEOAD and PCA and to further examine their genetic and...
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