Blood lipids and prostate cancer: a Mendelian randomization analysis.

doi:10.1002/cam4.695

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Article

Blood lipids and prostate cancer: a Mendelian randomization analysis.

Cancer medicine - 1 Jun 2016

Bull Caroline J, Bonilla Carolina, Holly Jeff M P, Perks Claire M, Davies Neil, Haycock Philip, Yu Oriana Hoi Yun, Richards J Brent, Eeles Rosalind, Easton Doug, Kote-Jarai Zsofia, Amin Al Olama Ali, Benlloch Sara, Muir Kenneth, Giles Graham G, MacInnis Robert J, Wiklund Fredrik, Gronberg Henrik, Haiman Christopher A, Schleutker Johanna, Nordestgaard Børge G, Travis Ruth C, Neal David, Pashayan Nora, Khaw Kay-Tee, Stanford Janet L, Blot William J, Thibodeau Stephen, Maier Christiane, Kibel Adam S, Cybulski Cezary, Cannon-Albright Lisa, Brenner Hermann, Park Jong, Kaneva Radka, Batra Jyotsna, Teixeira Manuel R, Micheal Agnieszka, Pandha Hardev, Smith George Davey, Lewis Sarah J, Martin Richard M

Abstract excerpt

Genetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer cases and 22,133 controls from 22 studies within the international PRACTICAL consortium were analyzed. Allele scores based on single nucleotide polymorphisms (SNPs) previously reported to be...

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PMID: 26992435
DOI: 10.1002/cam4.695
PMCID: PMC4924371

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