Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis.

doi:10.1002/ijc.30462

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Article

Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis.

International journal of cancer - 15 Jan 2017

Taylor Amy E, Martin Richard M, Geybels Milan S, Stanford Janet L, Shui Irene, Eeles Rosalind, Easton Doug, Kote-Jarai Zsofia, Amin Al Olama Ali, Benlloch Sara, Muir Kenneth, Giles Graham G, Wiklund Fredrik, Gronberg Henrik, Haiman Christopher A, Schleutker Johanna, Nordestgaard Børge G, Travis Ruth C, Neal David, Pashayan Nora, Khaw Kay-Tee, Blot William, Thibodeau Stephen, Maier Christiane, Kibel Adam S, Cybulski Cezary, Cannon-Albright Lisa, Brenner Hermann, Park Jong, Kaneva Radka, Batra Jyotsna, Teixeira Manuel R, Pandha Hardev, Donovan Jenny, Munafò Marcus R

Abstract excerpt

Coffee consumption has been shown in some studies to be associated with lower risk of prostate cancer. However, it is unclear if this association is causal or due to confounding or reverse causality. We conducted a Mendelian randomisation analysis to investigate the causal effects of coffee consumption on prostate cancer risk and progression. We used two genetic variants robustly associated with caffeine intake...

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PMID: 27741566
DOI: 10.1002/ijc.30462
PMCID: PMC5132137

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