Causal links of human serum metabolites on the risk of prostate cancer: insights from genome-wide Mendelian randomization, single-cell RNA sequencing, and metabolic pathway analysis.

Abstract excerpt

Background: Recently, serum metabolites have shown potential in predicting survival outcomes and may be related to the pathogenesis of prostate cancer. Nevertheless, the precise impact concerning the genetic effect of metabolites on prostate cancer risk remains obscure. In this context, we conducted a Mendelian randomization (MR) study aiming to explore the causality between genetically determined metabolites and...

Topics

Join the communities discussing this publication.

• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Metabolic Networks and Pathways
• Metabolome
• Prostatic Neoplasms