Article
Genetically predicted testosterone and systemic inflammation in men: a separate-sample Mendelian randomization analysis in older Chinese men.
PloS one - 1 Jan 2015
Zhao Jie, Jiang Chaoqiang, Lam Tai Hing, Liu Bin, Cheng Kar Keung, Xu Lin, Yeung Shiu Lun Au, Zhang Weisen, Leung Gabriel M, Schooling C Mary
Abstract excerpt
OBJECTIVES: Observationally, testosterone is negatively associated with systemic inflammation, but this association is open to both residual confounding and reverse causality. Large-scale randomized controlled trials (RCTs), assessing exogenous effects, are presently unavailable. We examined the association of endogenous testosterone with well-established systemic inflammatory markers (white blood cell,...
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