Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Circulating Selenium and Prostate Cancer Risk: A Mendelian Randomization Analysis.

Journal of the National Cancer Institute - 1 Sept 2018

Yarmolinsky James, Bonilla Carolina, Haycock Philip C, Langdon Ryan J Q, Lotta Luca A, Langenberg Claudia, Relton Caroline L, Lewis Sarah J, Evans David M, Davey Smith George, Martin Richard M

Abstract excerpt

In the Selenium and Vitamin E Cancer Prevention Trial (SELECT), selenium supplementation (causing a median 114 μg/L increase in circulating selenium) did not lower overall prostate cancer risk, but increased risk of high-grade prostate cancer and type 2 diabetes. Mendelian randomization analysis uses genetic variants to proxy modifiable risk factors and can strengthen causal inference in observational studies. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 2
Share to Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Odds Ratio

Share to Polymorphism, Single Nucleotide

Share to Prostatic Neoplasms

Share to Risk Assessment

Share to Risk Factors

Share to Selenium

Source

Open in PubMed Open full text

Identifiers

PMID: 29788239
DOI: 10.1093/jnci/djy081
PMCID: PMC6136927

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Circulating Selenium and Prostate Cancer Risk: A Mendelian Randomization Analysis.PMID 29788239Read ↗

Selenium and cancer risk: Wide-angled Mendelian randomization analysis.Semantic proximity Read ↗

Toenail selenium, plasma selenoprotein P and risk of advanced prostate cancer: A nested case-control study.Semantic proximity Read ↗

Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study.Semantic proximity Read ↗

Selenium- or Vitamin E-Related Gene Variants, Interaction with Supplementation, and Risk of High-Grade Prostate Cancer in SELECT.Semantic proximity Read ↗

Blood lipids and prostate cancer: a Mendelian randomization analysis.Semantic proximity Read ↗

Mendelian randomization does not support serum calcium in prostate cancer riskSemantic proximity Read ↗

Effects of selenium on coronary artery disease, type 2 diabetes and their risk factors: a Mendelian randomization study.Semantic proximity Read ↗

Effects of Selenium on Chronic Kidney Disease: A Mendelian Randomization Study.Semantic proximity Read ↗

Genetically predicted selenium concentrations and thyroid function: A two-sample Mendelian randomization study.Semantic proximity Read ↗

Genetically determined selenium concentrations and risk for autoimmune diseases.Semantic proximity Read ↗

A 28-year prospective analysis of serum vitamin E, vitamin E-related genetic variation and risk of prostate cancer.Semantic proximity Read ↗

A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.