Article
A Mendelian randomization analysis of circulating lipid traits and breast cancer risk.
International journal of epidemiology - 1 Aug 2020
Beeghly-Fadiel Alicia, Khankari Nikhil K, Delahanty Ryan J, Shu Xiao-Ou, Lu Yingchang, Schmidt Marjanka K, Bolla Manjeet K, Michailidou Kyriaki, Wang Qin, Dennis Joe, Yannoukakos Drakoulis, Dunning Alison M, Pharoah Paul D P, Chenevix-Trench Georgia, Milne Roger L, Hunter David J, Per Hall, Kraft Peter, Simard Jacques, Easton Douglas F, Zheng Wei
Abstract excerpt
BACKGROUND: Conventional epidemiologic studies have evaluated associations between circulating lipid levels and breast cancer risk, but results have been inconsistent. As Mendelian randomization analyses may provide evidence for causal inference, we sought to evaluate potentially unbiased associations between breast cancer risk and four genetically predicted lipid traits. METHODS: Previous genome-wide association...
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