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Article

Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

18 Mar 2013

Abstract excerpt

Accumulation of amyloid-β peptide (Aβ) in the brain is closely associated with cognitive decline in Alzheimer's disease (AD). Stereotaxic infusion of neprilysin-encoding viral vectors into the hippocampus has been shown to decrease Aβ in AD-model mice, but more efficient and global delivery is necessary to treat the broadly distributed burden in AD. Here we developed an adeno-associated virus (AAV) vector capable...

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PMID: 23503602
DOI: 10.1038/srep01472

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