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Article

Mutational profiles of different macroscopic subtypes of colorectal adenoma reveal distinct pathogenetic roles for KRAS, BRAF and PIK3CA.

BMC gastroenterology - 31 Dec 2014

Chang Li-Chun, Chiu Han-Mo, Shun Chia-Tung, Liang Jin-Tung, Lin Jaw-Town, Chen Chien-Chuan, Lee Yi-Chia, Wu Ming-Shiang

Abstract excerpt

BACKGROUND: Investigations of genetic alterations and correlations with histology or morphology could provide further insights into colorectal carcinogenesis. Nevertheless, such genetic changes were less investigated in adenoma stage and a comprehensive survey of oncogenic mutations in EGFR signaling pathway according to different morphologic subtypes has not been performed. METHODS: A total of 94 neoplasms,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25551625
DOI: 10.1186/s12876-014-0221-y
PMCID: PMC4296683

Genes

BRAF
KRAS
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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