Article
MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Oct 2013
da Cruz Heidi Lacerda Alves, da Silva Ronaldo Celerino, Segat Ludovica, de Carvalho Márcia Schneider Zuzarte de Mendonça Gomes, Brandão Lucas André Cavalcanti, Guimarães Rafael Lima, Santos Fabiana Cristina Fulco, de Lira Laís Ariane Siqueira, Montenegro Lilian Maria Lapa, Schindler Haiana Charifker, Crovella Sergio
Abstract excerpt
The innate immune system represents the first line of host defense against pathogens. Genetics factors regulating the immune responses play a role in the susceptibility to infectious diseases, such as tuberculosis (TB). We analyzed MBL2 promoter and exon 1 functional single nucleotide polymorphisms (SNPs) in a group of 155TB patients and 148 healthy controls in order to evaluate their influence on the onset of...
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