Article
Analysis of DEFB1 regulatory SNPs in cystic fibrosis patients from North-Eastern Italy.
International journal of immunogenetics - 1 Jun 2010
Segat L, Morgutti M, Athanasakis E, Trevisiol C, Amaddeo A, Poli F, Crovella S
Abstract excerpt
Cystic fibrosis (CF) transmembrane regulator protein (CFTR) gene is undoubtedly the main genetic factor involved in the modulation of CF phenotype. However, other factors such as human defensins and the genes encoding for these antimicrobial peptides have been hypothesized as possible modifiers influencing airways infection in CF patients, but their role in the pathogenesis of lung disease is still debated. Since...
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