Article
Differential distribution in vitamin D receptor gene variants and expression profile in Northeast Brazil influences upon active pulmonary tuberculosis.
Molecular biology reports - 1 Sept 2020
de Albuquerque Borborema Maria Eduarda, de Souza Pereira Jorge José, Dos Santos Peixoto Aline, Crovella Sergio, Schindler Haiana Charifker, da Silva Rabello Michelle Christiane, de Azevêdo Silva Jaqueline
Abstract excerpt
Tuberculosis is an infectious disease with variable outcomes. This variability is due to host immune capacity in containing the infection process initiated by the Mycobacterium tuberculosis (MTB). Vitamin D is able to modulate a very specific immune response against MTB infection, and its action relies on vitamin D receptor (VDR) binding. Altered VDR forms may compromise vitamin D pathway and proper immune...
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