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Article

Evidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence.

Nucleic acids research - 1 Jan 2006

Azam Mahrukh, Lee Julia Y, Abraham Veena, Chanoux Rebecca, Schoenly Kimberly A, Johnson F Brad

Abstract excerpt

RecQ DNA helicases, including yeast Sgs1p and the human Werner and Bloom syndrome proteins, participate in telomere biology, but the underlying mechanisms are not fully understood. Here, we explore the protein sequences and genetic interactors of Sgs1p that function to slow the senescence of telomerase (tlc1) mutants. We find that the S-phase checkpoint function of Sgs1p is dispensable for preventing rapid...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Rad52 DNA Repair and Recombination Protein

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Source

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Identifiers

PMID: 16428246
DOI: 10.1093/nar/gkj452
PMCID: PMC1342037

Genes

RAD52

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence.PMID 16428246Read ↗

Evidence that a RecQ helicase slows senescence by resolving recombining telomeres.Semantic proximity Read ↗

Sgs1 RecQ helicase inhibits survival of Saccharomyces cerevisiae cells lacking telomerase and homologous recombination.Semantic proximity Read ↗

SGS1 is required for telomere elongation in the absence of telomerase.Semantic proximity Read ↗

Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicaseSemantic proximity Read ↗

Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.Semantic proximity Read ↗

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases.Semantic proximity Read ↗

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase.Semantic proximity Read ↗

Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases.Semantic proximity Read ↗

Sumoylation and the structural maintenance of chromosomes (Smc) 5/6 complex slow senescence through recombination intermediate resolution.Semantic proximity Read ↗

Sgs1 Binding to Rad51 Stimulates Homology-Directed DNA Repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sumoylation of the BLM ortholog, Sgs1, promotes telomere–telomere recombination in budding yeastSemantic proximity Read ↗

Characterization of the slow-growth phenotype of S. cerevisiae Whip/Mgs1 Sgs1 double deletion mutants.Semantic proximity Read ↗

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