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Article

Type I Interferons Regulate the Magnitude and Functionality of Mouse Polyomavirus-Specific CD8 T Cells in a Virus Strain-Dependent Manner.

Journal of virology - 15 May 2016

Qin Qingsong, Shwetank, Frost Elizabeth L, Maru Saumya, Lukacher Aron E

Abstract excerpt

UNLABELLED: Mouse polyomavirus (MPyV) is a ubiquitous persistent natural mouse pathogen. A glutamic acid (E)-to-glycine (G) difference at position 91 of the VP1 capsid protein shifts the profile of tumors induced by MPyV from an epithelial to a mesenchymal cell origin. Here we asked if this tropism difference affects the MPyV-specific CD8 T cell response, which controls MPyV infection and tumorigenesis. Infection...

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Source

Open in PubMed Open full text

Identifiers

PMID: 26984726
DOI: 10.1128/JVI.00199-16
PMCID: PMC4859723

Genes

KLRG1
PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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