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Article

Host Genetic Variation Has a Profound Impact on Immune Responses Mediating Control of Viral Load in Chronic Gammaherpesvirus Infection.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2023

Holt Emily A, Waytashek Courtney M, Sessions Katherine J, Asarian Loredana, Lahue Karolyn G, Usherwood Edward J, Teuscher Cory, Krementsov Dimitry N

Abstract excerpt

Chronic infection with the gammaherpesvirus EBV is a risk factor for several autoimmune diseases, and poor control of EBV viral load and enhanced anti-EBV responses elevate this risk further. However, the role of host genetic variation in the regulation of immune responses to chronic gammaherpesvirus infection and control of viral replication remains unclear. To address this question, we infected C57BL/6J (B6)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37819784
DOI: 10.4049/jimmunol.2300294
PMCID: PMC10841120

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