Article

Modeling PPRV pathogenesis in mice to assess the contribution of innate cells and anti-viral T cells

2020-10-28

Abstract excerpt

We demonstrate a rapid induction of type I IFN response in PPRV stimulated cells and the susceptibility of mice, genetically ablated of interferon response, to PPRV infection. Following PPRV infection, IFNR KO mice gradually reduced their body weights and succumbed to the infection within 10 days. While the infecting inoculum size did not alter the outcome of infection, the nature of the induced disease was qualit...

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Literature Corpus work: 2f3ff945-352d-5f54-87c4-8f5bb02330a4
DOI: 10.1101/2020.10.27.358309

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