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Article

Beta 2-microglobulin knockout mice are highly susceptible to polyoma virus tumorigenesis.

Virology - 5 Dec 1998

Drake D R, Lukacher A E

Abstract excerpt

Polyoma virus is highly oncogenic when inoculated into immunocompromised adult mice and neonatal mice of specific inbred strains. Although T lymphocytes are known to be essential in controlling polyoma virus tumorigenesis, the importance of class I MHC-restricted CD8+ T cells in mediating tumor resistance remains unclear. Here, we investigated the tumorigenicity of polyoma virus in adult mice rendered CD8+ T...

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Identifiers

PMID: 9875336
DOI: 10.1006/viro.1998.9455

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