Article
Beta 2-microglobulin knockout mice are highly susceptible to polyoma virus tumorigenesis.
Virology - 5 Dec 1998
Drake D R, Lukacher A E
Abstract excerpt
Polyoma virus is highly oncogenic when inoculated into immunocompromised adult mice and neonatal mice of specific inbred strains. Although T lymphocytes are known to be essential in controlling polyoma virus tumorigenesis, the importance of class I MHC-restricted CD8+ T cells in mediating tumor r...
Topics
- Animals
- Antibodies, Viral
- Blotting, Southern
- Blotting, Western
- DNA, Viral
- Genetic Predisposition to Disease
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Papillomavirus Infections
- Polymerase Chain Reaction
- Polyomavirus
- Tumor Virus Infections
- beta 2-Microglobulin