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CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection.

Cell reports - 31 May 2012

Sehrawat Sharvan, Kirak Oktay, Koenig Paul-Albert, Isaacson Marisa K, Marques Sofia, Bozkurt Gunes, Simas J Pedro, Jaenisch Rudolph, Ploegh Hidde L

Abstract excerpt

To study the CD8(+) T cell response against a mouse γ-herpes virus, we generated K(b)-MHV-68-ORF8(604-612)RAG(-/-) CD8(+) T cell receptor transnuclear (TN) mice as a source of virus-specific CD8(+) T cells. K(b)-ORF8-Tet(+) CD8(+) T cells, expanded in the course of a resolving MHV-68 infection, s...

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Identifiers

PMID: 22832272
DOI: 10.1016/j.celrep.2012.03.009
PMCID: PMC3406328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22832272-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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