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Article

A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology.

The Journal of experimental medicine - 17 Mar 2008

Evans Andrew G, Moser Janice M, Krug Laurie T, Pozharskaya Veranika, Mora Ana L, Speck Samuel H

Abstract excerpt

Little is known about herpesvirus modulation of T cell activation in latently infected individuals or the implications of such for chronic immune disorders. Murine gammaherpesvirus 68 (MHV68) elicits persistent activation of CD8(+) T cells bearing a Vbeta4(+) T cell receptor (TCR) by a completely...

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Share to CD8-Positive T-Lymphocytes
Share to Herpesviridae Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interferon gamma Receptor

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

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Identifiers

PMID: 18332178
DOI: 10.1084/jem.20071135
PMCID: PMC2275388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18332178-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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