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Article

Low Ten-eleven-translocation 2 (TET2) transcript level is independent of TET2 mutation in patients with myeloid neoplasms.

Diagnostic pathology - 16 Mar 2016

Scopim-Ribeiro Renata, Machado-Neto João Agostinho, de Melo Campos Paula, Niemann Fernanda Soares, Lorand-Metze Irene, Costa Fernando Ferreira, Olalla Saad Sara Teresinha, Traina Fabiola

Abstract excerpt

BACKGROUND: New sequencing technologies have enabled the identification of mutations in Ten-eleven-translocation 2 (TET2), an enzyme that catalyzes the conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5-hmC) in myeloid neoplasms. We have recently identified reduced TET2 mRNA expression in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), which is associated with a poor overall survival...

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Identifiers

PMID: 26984174
DOI: 10.1186/s13000-016-0476-4
PMCID: PMC4793581

Genes

TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Low Ten-eleven-translocation 2 (TET2) transcript level is independent of TET2 mutation in patients with myeloid neoplasms.PMID 26984174Read ↗

Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes.Semantic proximity Read ↗

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TET2 expression is a potential prognostic and predictive biomarker in cytogenetically normal acute myeloid leukemiaSemantic proximity Read ↗

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