Article
Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value.
Blood - 11 Nov 2010
Smith Alexander E, Mohamedali Azim M, Kulasekararaj Austin, Lim ZiYi, Gäken Joop, Lea Nicholas C, Przychodzen Bartlomiej, Mian Syed A, Nasser Erick E, Shooter Claire, Westwood Nigel B, Strupp Corinna, Gattermann Norbert, Maciejewski Jaroslaw P, Germing Ulrich, Mufti Ghulam J
Abstract excerpt
Mutations in the TET2 gene are frequent in myeloid disease, although their biologic and prognostic significance remains unclear. We analyzed 355 patients with myelodysplastic syndromes using "next-generation" sequencing for TET2 aberrations, 91 of whom were also subjected to single-nucleotide polymorphism 6.0 array karyotyping. Seventy-one TET2 mutations, with a relative mutation abundance (RMA) ≥ 10%, were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.