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Article

TET2 deletions are a recurrent but rare phenomenon in myeloid malignancies and are frequently accompanied by TET2 mutations on the remaining allele.

British journal of haematology - 1 Jan 2012

Bacher Ulrike, Weissmann Sandra, Kohlmann Alexander, Schindela Sonja, Alpermann Tamara, Schnittger Susanne, Kern Wolfgang, Haferlach Torsten, Haferlach Claudia

Abstract excerpt

TET2 mutations have been identified in 10-25% of patients with myeloid malignancies, but TET2 gene copy number alterations remain to be evaluated. We performed interphase and metaphase fluorescence in situ hybridization (FISH), using newly designed probes that span TET2, in 893 patients with acute myeloid leukaemia (AML) and chronic myeloid malignancies and validated the new assay by single nucleotide...

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Identifiers

PMID: 22017486
DOI: 10.1111/j.1365-2141.2011.08911.x

Genes

TET2
JAK2

Variants

Provenance

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TET2 deletions are a recurrent but rare phenomenon in myeloid malignancies and are frequently accompanied by TET2 mutations on the remaining allele.PMID 22017486Read ↗

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Low Ten-eleven-translocation 2 (TET2) transcript level is independent of TET2 mutation in patients with myeloid neoplasms.Semantic proximity Read ↗

Number and type of TET2 mutations in chronic myelomonocytic leukemia and their clinical relevanceSemantic proximity Read ↗

Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevanceSemantic proximity Read ↗

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Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AMLSemantic proximity Read ↗

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