Article
Role of PALB2 Polymorphisms with Regard to Susceptibility to Female Breast Cancer Risk in the Chinese Population.
Genetic testing and molecular biomarkers - 1 May 2016
Jiang Weichao, Zhuang Chunbo, Zheng Lei, Wang Xiaobei
Abstract excerpt
AIMS: PALB2 (partner and localizer of BRCA2) is a nuclear partner of BRCA2 and promotes its localization and stability in the nucleus, allowing it to function in DNA repair and at the S-phase checkpoint. It has been hypothesized that polymorphisms in the PALB2 gene may be associated with tumorigenesis, particularly with respect to susceptibility to breast cancer. METHODS: To assess the association of...
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