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Article

Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer.

Breast cancer research and treatment - 1 Dec 2017

Zhang Kun, Zhou Jiaojiao, Zhu Xuan, Luo Meng, Xu Chunjing, Yu JieKai, Deng Mei, Zheng Shu, Chen Yiding

Abstract excerpt

BACKGROUND: PALB2 (Partner and Localizer of BRCA2) is recently recognized as a breast cancer predisposition gene. Germline loss-of-function mutations in PALB2 lead to increased breast cancer risk. Since the germline mutation frequency of PALB2 is much less than BRCA1/2, the distinct mutation spectrum of PALB2 is still obscure. To verify the utility of PALB2 genetic testing in Chinese population, we assessed the...

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Source

Identifiers

PMID: 28825143
DOI: 10.1007/s10549-017-4425-z

Genes

PALB2
BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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